Phosphatidylinositol-3-kinase Related Kinases (pikks) in Radiation-induced Dna Damage
نویسندگان
چکیده
An efficient cancer treatment means to restore controlled tissue growth via interfering with cell signalling pathways regulating cell-cycle and apoptosis. Among many treatment strategies, targeted cancer therapy and radiation play a pivotal role. Since cancer is one of the leading causes of death worldwide, it is reasonable to invest time and resources in the enlightening of mechanisms, which underlie radio-resistance.
منابع مشابه
Emerging common themes in regulation of PIKKs and PI3Ks
Phosphatidylinositol-3 kinase-related kinases (PIKKs) comprise a family of protein kinases that respond to various stresses, including DNA damage, blocks in DNA replication, availability of nutrients and errors in mRNA splicing. PIKKs are characterized by the presence of a conserved kinase domain (KD), whose activity is regulated by two C-terminal regions, referred to as PIKK-regulatory domain ...
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